Octopus is a revolutionary trial that will transform the way we test treatments for progressive MS. A smarter way of testing potential treatments, it could deliver life-changing new treatments up to three times faster. Octopus uses what’s called a multi-arm, multi-stage (MAMS) design – the first time this has even been done in MS. Merging separate trials may sound obvious. But launching a MAMS trial for MS needs so many things to line up perfectly. From hospitals around the country equipped to be trial sites, to the incredibly complicated statistics that underpin the design.
A snapshot of Octopus numbers so far
Octopus hospital sites are now telephoning people who have identified them as their preferred hospital. If the telephone conversation shows applicants appear to be eligible for the trial, they will be asked to go to their chosen site to sign consent and have the tests needed prior to joining the trial.
We are pleased to let you know that so far:
· 275 potential participants have been through telephone screening by their chosen site.
· 134 have attended their chosen hospital site for further screening and to give consent.
· 101 participants have entered the Octopus trial and started trial treatment.
Stage 1 (expected until December 2024) – we hope to enrol 375 participants.
Stage 2 (expected to recruit between January 2025 and December 2028) aims to recruit at least a further 1200 participants.
We are pleased to share that the trial is now open in 10 UK hospital sites:
· Addenbrooke’s Hospital (Cambridge)
· Belfast City Hospital
· Leeds General Infirmary
· Poole Hospital
· Royal Hallamshire Hospital (Sheffield)
· The Anne Rowling Regenerative Neurology Clinic (Edinburgh)
· University College Hospital London (UCLH)
· University Hospitals of Coventry and Warwickshire
· University Hospital Southampton
· University Hospital of Wales (Cardiff)
Work also continues to open other hospital sites around the UK. Some may take longer to open than others; the time taken includes getting local approvals, setting up contracts, arranging MRI scan providers, as well as training researchers at each site.
PLATYPUS – Octopus in Australia
You may also have seen news about sites opening in Australia in a part of a sister trial called PLATYPUS. If you would like to read more about PLATYPUS, please follow this link.
The Octopus trial will continue to share updates around every 3 months. But please also do keep checking the Octopus website, which provides further information on the details of the trial, including when hospital sites open, and frequently asked questions and news about sites and the trial.
For information on MS research and for practical support for MS, please refer to the MS Society website.
If you would like to know about other MS Clinical trials available, please follow this link.
We thank you again for your patience. We look forward to an increase in the rate that participants are contacted as more sites get opened and working with you to make OCTOPUS a success.
If you are interested in learning more about OCTOPUS or registering, please follow this link for more information.